Cosmetics are the most widely applied products to the skin and include creams, lotions, gels and sprays. Their formulation, design and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects.
Are Topical Skin Penetration Enhancers Safe?
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement | SpringerLink
More particularly, this invention relates to the use of esters of one or more fatty acids and lactic acid salts as permeation enhancers when formulated with aqueous emulsion based pressure sensitive adhesives resulting in the formation of matrix patch devices for the transdermal delivery of a wide range of active permeants. ART The transdermal administration of drugs is becoming increasingly accepted as a preferred mode of delivery. Transdermal delivery of drugs provides many advantages over conventional oral administration. Advantages of transdermal systems include convenience, noninterrupted therapy, improved patient compliance, reversibility of treatment by removal of the system from the skin , elimination of "hepatic first pass" effect, the high degree of control over blood concentration of any particular drug and consequent reduction of side effects. Although transdermal systems have many advantages, most drugs are not amenable to this mode of administration due to the well known barrier properties of the skin. Molecules moving from the environment into and through intact skin must first penetrate the stratum corneum and any material on its surface. The molecule must then penetrate the viable epidermis, the papillary dermis, and then the capillary walls and into systemic circulation.
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement
As I mentioned in my post last week, molecules don't penetrate or absorb the skin as easily as one would think. Consumers these days are a lot more conscious about what they put on their skin and are definitely a lot more skeptical. Can it really alter my DNA? Can it get rid of my acne?
The safety of topically applying skincare and cosmetic ingredients has been in question, especially as attempted legislation in regard to our industry continues to raise alarm bells without scientific clarity. We deal with so many misnomers and hype on a daily basis which includes marketing provided for certain cosmetic ingredients, good or bad. Watchdog groups also want to muddy our thinking by making claims that penetration enhancers utilized in cosmetics and skincare are spreading poisons into our bodies at an alarming rate. But let's not get carried away from the actual science here or allow emotive jargon to cloud our judgment.